Birdshot retionchoroidopathy is a chronic inflammatory disease of the eye,with a presumed autoimmune basis. There is a strong HLA association (HLA-A29). We have begun to study the repertoire of the variable region of the beta chain of the T-cell receptor in patients and controls. The analysis is directed to characterize the central steps of autoimmune recognition and its regulation, facilitating the study of the magnitude of autoreactive T cell clonal expansion in this disease. Studies are ongoing with no results to report.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000378-01
Application #
6507407
Study Section
(LI)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code