In 2007 the investigative team published a paper to share, in a peer-review format, the collective idease underlying the conceptual framework for the study (see bibliography). This paper presents, in great detail, the rationale for the AGES study, its design, select findings from previous investigations in the cohort during mid-life, and future analytic plans.? ? In the AGES cohort we found evidence of brain microbleeds was found in 485 (11.5%) people; 192 people had multiple microbleeds. People with signs of retinal microvascular lesions were significantly more likely to have multiple cerbral microbleeds than were people without retinal microvascular lesions. Retinal microvascular abnormalities and microbleeds in the brain microbleeds may occur together in older adults, particularly in people with diabetes.? ? A follow-up examination on a subset of 4,000 elderly individuals in this cohort was initiated at the end of 2007. ? ? For more information on the study, see www.hjarta.is/english/ages ? ? See also Z01 AG007380 (Dr. Harris).

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000401-07
Application #
7734620
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2008
Total Cost
$106,276
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Thorsteinsdottir, Ingunn; Aspelund, Thor; Gudmundsson, Elias et al. (2016) High-Sensitivity Cardiac Troponin I Is a Strong Predictor of Cardiovascular Events and Mortality in the AGES-Reykjavik Community-Based Cohort of Older Individuals. Clin Chem 62:623-30
Steingrimsdottir, Laufey; Halldorsson, Thorhallur I; Siggeirsdottir, Kristin et al. (2014) Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D. PLoS One 9:e91122
Jonasson, Fridbert; Arnarsson, Arsaell; EirĂ­ksdottir, Gudny et al. (2011) Prevalence of age-related macular degeneration in old persons: Age, Gene/environment Susceptibility Reykjavik Study. Ophthalmology 118:825-30
Ikram, M Kamran; Sim, Xueling; Xueling, Sim et al. (2010) Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLoS Genet 6:e1001184
Qiu, Chengxuan; Cotch, Mary Frances; Sigurdsson, Sigurdur et al. (2009) Microvascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik study. Ann Neurol 65:569-76
Qiu, Chengxuan; Cotch, Mary Frances; Sigurdsson, Sigurdur et al. (2008) Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study. Diabetes 57:1645-50
Harris, Tamara B; Launer, Lenore J; Eiriksdottir, Gudny et al. (2007) Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol 165:1076-87