The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter, cohort study in which a population-based sample of 6,814 Caucasian, Hispanic, African-American and Asian-American men and women aged 45-84 with subclinical cardiovascular disease are followed for 10 years to identify factors predictive of progression to overt cardiovascular disease. The MESA study is sponsored by NHLBI and is funded under contract. Dr. Cotch is a collaborator in the MESA-EYE component (refraction and fundus photography). The ocular component was integrated into the second MESA visit and 6235 people participated between September 2002 and December 2003.
The aims of the ocular component are to document the presence and severity of retinal microvascular changes (as interpreted from digital retinal photos) indicative of macular degeneration and diabetic retinopathy, as well as to describe their interrelationships with cross-sectional and longitudinal measures of microvascular and macrovascular systemic disease as defined clinically, by imaging modality, or by analysis of biological laboratory measures. The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, determine the degree to which visual impairment could be reduced with better refractive correction, and correlate visual findings with retinal pathology. The ocular data are being cleaned in conjunction with the data coordinating center. In 2004, several manuscript proposals have been submitted and approved by the MESA study leadership. After the data become available to the study investigators (likely to occur in 2005), analysis will proceed.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000403-03
Application #
6968594
Study Section
(EPIB)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2004
Total Cost
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Liang, Dongchun; Zuo, Aijun; Shao, Hui et al. (2013) Retinoic acid inhibits CD25+ dendritic cell expansion and ?? T-cell activation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 54:3493-503
Yau, Joanne Wen Yee; Xie, Jing; Lamoureux, Ecosse et al. (2012) Retinal microvascular calibre and risk of incident diabetes: the multi-ethnic study of atherosclerosis. Diabetes Res Clin Pract 95:265-74
Greenstein, Max B; Myers, Chelsea E; Meuer, Stacy M et al. (2011) Prevalence and characteristics of choroidal nevi: the multi-ethnic study of atherosclerosis. Ophthalmology 118:2468-73
Kawasaki, Ryo; Cheung, Ning; Islam, F M Amirul et al. (2011) Is diabetic retinopathy related to subclinical cardiovascular disease? Ophthalmology 118:860-5
Yau, Joanne Wen Yee; Xie, Jing; Kawasaki, Ryo et al. (2011) Retinal arteriolar narrowing and subsequent development of CKD Stage 3: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 58:39-46
Ng, Ching Hui; Cheung, Ning; Wang, Jie Jin et al. (2011) Prevalence and risk factors for epiretinal membranes in a multi-ethnic United States population. Ophthalmology 118:694-9
Adar, Sara D; Klein, Ronald; Klein, Barbara E K et al. (2010) Air Pollution and the microvasculature: a cross-sectional assessment of in vivo retinal images in the population-based multi-ethnic study of atherosclerosis (MESA). PLoS Med 7:e1000372
Nguyen, Thanh T; Islam, F M Amirul; Farouque, H M Omar et al. (2010) Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis. Stroke 41:1343-8
Jensen, Richard A; Shea, Steven; Ranjit, Nalini et al. (2010) Psychosocial risk factors and retinal microvascular signs: the multi-ethnic study of atherosclerosis. Am J Epidemiol 171:522-31
Kreis, Andreas J; Wong, Tien Yin; Islam, F M Amirul et al. (2009) Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA). Diab Vasc Dis Res 6:40-2

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