The purpose of this project is to assess the effect of polychlorinated biphenyls (PCBs) and pesticides on female fecundity and fertility. This project is a part of a larger study entitled the New York State Angler Cohort Study (H75/ATH298328) whose purpose is to characterize exposures to various environmental contaminants, and to determine whether human health has been adversely affected among a cohort of angler families residing in the Great Lakes Basin of New York State. Specifically, 102 women who were planning to discontinue contraception to become pregnant were followed for 12 at risk menstrual cycles. All women completed baseline interviews and 90 provided blood specimens. Women were instructed in the use of home pregnancy kits and in the completion of daily diaries that were used to record menstruation, sexual intercourse, pregnancy test results, and select behaviors (i.e., cigarette smoking, caffeine and alcohol consumption, vitamin usage, and fish consumption). Additional blood specimens were obtained from women upon becoming pregnant and after delivery for women whose pregnancies resulted in a live birth. Toxicological analysis of blood specimens was conducted using gas chromatography with electron capture for 66 PCB congeners and 7 pesticides. Data analysis is currently underway to determine whether female fecundity, as measured by time-to-pregnancy, is adversely affected by PCB congeners and/or pesticides along with other relevant fecundity endpoints (viz., pregnancy loss, menstruation and infertility).
| Lum, Kirsten J; Sundaram, Rajeshwari; Buck Louis, Germaine M et al. (2016) A Bayesian joint model of menstrual cycle length and fecundity. Biometrics 72:193-203 |
| Trabert, Britton; Chen, Zhen; Kannan, Kurunthachalam et al. (2015) Persistent organic pollutants (POPs) and fibroids: results from the ENDO study. J Expo Sci Environ Epidemiol 25:278-85 |
| Place, Ned J; Coscia, Elizabeth M; Dahl, Nancy J et al. (2011) The anti-androgen combination, flutamide plus finasteride, paradoxically suppressed LH and androgen concentrations in pregnant spotted hyenas, but not in males. Gen Comp Endocrinol 170:455-9 |
| Cooney, Maureen A; Buck Louis, Germaine M; Sundaram, Rajeshwari et al. (2009) Validity of self-reported time to pregnancy. Epidemiology 20:56-9 |
| Ferrari, R M; Cooney, M A; Vexler, A et al. (2007) Time to pregnancy and multiple births. Hum Reprod 22:407-13 |
| Taylor, Kira C; Jackson, Leila W; Lynch, Courtney D et al. (2007) Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratio. Environ Res 103:99-105 |
| Buck Louis, Germaine M; Lynch, Courtney D; Cooney, Maureen A (2006) Environmental influences on female fecundity and fertility. Semin Reprod Med 24:147-55 |
| Schisterman, Enrique F; Whitcomb, Brian W; Louis, Germaine M Buck et al. (2005) Lipid adjustment in the analysis of environmental contaminants and human health risks. Environ Health Perspect 113:853-7 |
| Rockett, John C; Buck, Germaine M; Lynch, Courtney D et al. (2004) The value of home-based collection of biospecimens in reproductive epidemiology. Environ Health Perspect 112:94-104 |
| Buck, Germaine M; Lynch, Courtney D; Stanford, Joseph B et al. (2004) Prospective pregnancy study designs for assessing reproductive and developmental toxicants. Environ Health Perspect 112:79-86 |
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