Previous collaborations with Dr. Svetkey suggested evidence for linkage between a marker on chromosome 5, at or near the beta-2-adrenergic receptor, that was responsible, at least in part, for the phenotypic variation of diastolic blood pressure after salt loading and depletion. Additional genotyping of markers flanking the putative locus failed to show evidence of linkage, although the previous finding was corroborated using the variance-components method of linkage analysis. The estimated recombination fractions between the flanking markers were considerably larger in this population of predominantly female African- Americans than reported in other populations. Estimates of heritability suggest that at least some of the traits related to salt- sensitivity are high, suggesting that genetic components may play a substantial role in the expression of blood pressure after exposure to salt loading. - hypertension, beta-2-adrenergic receptor, linkage analysis, candidate loci, African-Americans, salt-sensitivity - Human Subjects

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Intramural Research (Z01)
Project #
1Z01HG000106-03
Application #
6290317
Study Section
Special Emphasis Panel (IDRB)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
National Human Genome Research Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code