Newborns with congestive heart failure are universally treated with digitalis compounds. The hypothesis tested in these studies is that this drug is deleterious in the setting of ischemia and reperfusion because of Na/k. ATPase inhibition of abnormally low concentrations of this enzyme. Newborn pigs will be treated with digoxin for five days in clinically relevant doses. Treated and non-treated hearts will have intracellular myocardial sodium and calcium concentrations determine. Three groups of 20 hearts each will be placed on an isolated working heart apparatus. Ischemia and reperfusion will be used and contractility functions assessed together with biochemical analyses. Age matched non-treated controls will be used.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL002798-03
Application #
3899195
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
United States
Zip Code