Abstract

We have continued to develop the hardware, MR pulse sequences and data analysis software to perform high resolution mechanical function maps while simultaneously recording electrical activation maps from an electrode """"""""sock"""""""" surrounding the heart. We have also developed the hardware to perform endocardial mapping simultaneously with the epicardial mapping using a basket electrode. The electrical recording system has been made MR compatible so that the MR image quality is not degraded by the presence of the sock around the heart. Coupled electromechanical activation maps are being generated by registration of the electrical maps with the mechanical maps generated from MRI tagging studies. The effect of ischemia on the electromechanical can now be studied in detail, perhaps leading to the ability to precisely distinguish viable from non-viable tissue. A series of experiments is currently being done which maps both the electrical and mechanical behavoir of the heart DURING ventricular tachycardia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL004609-05
Application #
6967060
Study Section
Cancer Etiology Study Section (CE)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2004
Total Cost
Indirect Cost

  Institution

Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Ashikaga, Hiroshi; Estner, Heidi L; Herzka, Daniel A et al. (2014) Quantitative Assessment of Single-Image Super-Resolution in Myocardial Scar Imaging. IEEE J Transl Eng Health Med 2:
Sampath, Smita; Derbyshire, John Andrew; Ledesma-Carbayo, Maria J et al. (2011) Imaging left ventricular tissue mechanics and hemodynamics during supine bicycle exercise using a combined tagging and phase-contrast MRI pulse sequence. Magn Reson Med 65:51-9
Ashikaga, Hiroshi; Leclercq, Christophe; Wang, Jiangxia et al. (2010) Hemodynamic improvement in cardiac resynchronization does not require improvement in left ventricular rotation mechanics: three-dimensional tagged MRI analysis. Circ Cardiovasc Imaging 3:456-63
Hopenfeld, Bruce; Ashikaga, Hiroshi (2010) Origin of the electrocardiographic U wave: effects of M cells and dynamic gap junction coupling. Ann Biomed Eng 38:1060-70
Guttman, Michael A; Raval, Amish N; Lederman, Robert J et al. (2008) Real-time catheter-directed MRA with effective background suppression and persistent rendering. J Magn Reson Imaging 28:538-42
Ashikaga, Hiroshi; Sasano, Tetsuo; Dong, Jun et al. (2007) Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation. Circ Res 101:939-47
Ciaccio, Edward J; Ashikaga, Hiroshi; Kaba, Riyaz A et al. (2007) Model of reentrant ventricular tachycardia based on infarct border zone geometry predicts reentrant circuit features as determined by activation mapping. Heart Rhythm 4:1034-45
Hopenfeld, Bruce; Ashikaga, Hiroshi; McVeigh, Elliot R (2007) Geodesic based registration of sensor data and anatomical surface image data. Ann Biomed Eng 35:1771-81
Sampath, Smita; Raval, Amish N; Lederman, Robert J et al. (2007) High-resolution 3D arteriography of chronic total peripheral occlusions using a T1-W turbo spin-echo sequence with inner-volume imaging. Magn Reson Med 57:40-9
Moreau-Villeger, Valerie; Delingette, Herve; Sermesant, Maxime et al. (2006) Building maps of local apparent conductivity of the epicardium with a 2-D electrophysiological model of the heart. IEEE Trans Biomed Eng 53:1457-66

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