Abstract

During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions.? ? We are developing clinical-grade catheter devices to recanalize chronic total occlusions of peripheral arteries. Other catheter devices also are under development for real-time MRI procedures in animals and for novel X-ray guided procedures.? ? We are developing catheter-based mitral annuloplasty to treat functional mitral valve regurgitation. We have additional success in porcine models of ischemic cardiomyopathy mitral valve regurgitation.? ? We continue to develop methods to combine or fuse prior MRI-derived regions of interest with real-time X-ray during preclinical and clinical catheter-based procedures. For example, our X-ray Fused with MRI (XFM) system enables a novel approach to non-surgical mitral valve repair. We also demonstrated XFM guided repair of membranous ventricular septal defect, a congenital heart disease usually requiring surgical repair.? ? We continue to prepare for clinical testing of real-time MRI to treat human disease, including obstructive peripheral artery atherosclerosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL005062-06
Application #
7735004
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2008
Total Cost
$2,844,293
Indirect Cost

  Institution

Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Campbell-Washburn, Adrienne E; Rogers, Toby; Stine, Annette M et al. (2018) Right heart catheterization using metallic guidewires and low SAR cardiovascular magnetic resonance fluoroscopy at 1.5 Tesla: first in human experience. J Cardiovasc Magn Reson 20:41
Ramasawmy, Rajiv; Rogers, Toby; Alcantar, Miguel A et al. (2018) Blood volume measurement using cardiovascular magnetic resonance and ferumoxytol: preclinical validation. J Cardiovasc Magn Reson 20:62
Rogers, Toby; Ratnayaka, Kanishka; Khan, Jaffar M et al. (2017) CMR fluoroscopy right heart catheterization for cardiac output and pulmonary vascular resistance: results in 102 patients. J Cardiovasc Magn Reson 19:54
Rogers, Toby; Mahapatra, Srijoy; Kim, Steven et al. (2016) Transcatheter Myocardial Needle Chemoablation During Real-Time Magnetic Resonance Imaging: A New Approach to Ablation Therapy for Rhythm Disorders. Circ Arrhythm Electrophysiol 9:e003926
Rogers, Toby; Ratnayaka, Kanishka; Karmarkar, Parag et al. (2016) Real-time magnetic resonance imaging guidance improves the diagnostic yield of endomyocardial biopsy. JACC Basic Transl Sci 1:376-383
Campbell-Washburn, Adrienne E; Xue, Hui; Lederman, Robert J et al. (2016) Real-time distortion correction of spiral and echo planar images using the gradient system impulse response function. Magn Reson Med 75:2278-85
McGuirt, Delaney; Mazal, Jonathan; Rogers, Toby et al. (2016) X-ray Fused With Magnetic Resonance Imaging to Guide Endomyocardial Biopsy of a Right Ventricular Mass. Radiol Technol 87:622-6
Ratnayaka, Kanishka; Rogers, Toby; Schenke, William H et al. (2016) Magnetic Resonance Imaging-Guided Transcatheter Cavopulmonary Shunt. JACC Cardiovasc Interv 9:959-70
Mazal, Jonathan R; Rogers, Toby; Schenke, William H et al. (2016) Interventional-Cardiovascular MR: Role of the Interventional MR Technologist. Radiol Technol 87:261-70
Campbell-Washburn, Adrienne E; Faranesh, Anthony Z; Lederman, Robert J et al. (2015) Magnetic Resonance Sequences and Rapid Acquisition for MR-Guided Interventions. Magn Reson Imaging Clin N Am 23:669-79

Showing the most recent 10 out of 71 publications