The distribution of positron emitting substances in brain can be followed by positron emission tomography (PET). We are developing 18F-labeled high affinity opiate drugs to be injected into living humans for the visualization of opiate receptor patterns in vivo. It will be interesting to determine whether opiate receptor distribution patterns in cortex change as a function of attention and emotional states. Meanwhile, we have carefully documented the receptor-binding properties and kinetics of 3H-cyclofoxy in rat brain after in vivo injection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002182-06
Application #
3944712
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code