Computerized image analysis of MRIs has proved to be a valid method of assessing volume in vivo of selected brain structures. The use of one such system (LOATS) enables one to determine the size of such structures as frontal lobe, temporal lob, caudate, thalamus, and corpus callosum in various coronal and sagittal plains through the use of an edge finding function. In addition, gray matter can be distinguished from white matter and the ventricular system size can be delineated. These measurements can, in turn, be correlated with performance on various neuropsychological measures including Verbal IQ. Performance IQ, Wechsler Memory Scale MQ and Halstead- Reitan average impairment rating. Volumetric reductions in specific brain areas may, in fact, be associated with focal neuropsychological deficits.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002434-02
Application #
3922055
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code