S-Adenosyl-L-methionine (AdoMet) is a safe and probably effective antidepressant agent in certain forms of clinical depression. AdoMet is synthesized in every cell by methionine-adenosyltransferase (MAT). In higher mammals there are several tissue specific MAT isozymes differing in kinetic and molecular properties. We postulate that certain forms of clinical depression are due to a deficiency of brain MAT and that the therapeutic effects of AdoMet are related to its ability to correct this biochemical defect.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002462-05
Application #
3781416
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code