Studies have shown that schizophrenics respond to the reinstatement of neuroleptics in a characteristic pattern, but there is disagreement about the mechanism underlying symptom change. To clarify this issue, double-blind, serial measurements of the behavior and symptom change of schizophrenic subjects who resumed neuroleptic medication after a drug-free period were analyzed. Fifty percent of the response occurred by the seventh day of post-drug reinstatement, including a significant improvement in symptom/behavior inventory subscales measuring delusions, hallucinations, and other positive symptoms associated with psychosis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002544-03
Application #
3845335
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code