Abstract

My colleagues in the National Human Genome Research Institute and I have continued to study a number of complex and Mendelian genetic traits in humans. We have made excellent progress in our search for a prostate cancer gene on the X chromosome. We have completed a genome- wide search for linkage in samples from Australian families with > 3 cases of melanoma, families on Kosrae with schizophrenia, and a large kindred with autosomal dominant osteopetrosis. In addition, we have spent a good deal of time forging collaborative ties to scientists in North Africa and anticipate having a number of new samples sets to study in the next year or two. On other fronts, we have begun working on the Mammalian Gene Collection, the goal of which is to clone and sequence full-length cDNAs corresponding to all human transcripts, and plan to begin making mouse expression arrays to help achieve the goals of the Brain Molecular Anatom. - genetics, linkage, cancer, melanoma, schizophrenia, Parkinsonism - Human Subjects

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002771-02
Application #
6290604
Study Section
Special Emphasis Panel (LG)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Mutsuga, Noriko; Shahar, Tal; Verbalis, Joseph G et al. (2004) Selective gene expression in magnocellular neurons in rat supraoptic nucleus. J Neurosci 24:7174-85
Ahn, Joon-Ik; Lee, Ki-Hwan; Shin, Dong-Mi et al. (2004) Comprehensive transcriptome analysis of differentiation of embryonic stem cells into midbrain and hindbrain neurons. Dev Biol 265:491-501
Xiang, Charlie C; Brownstein, Michael J (2003) Preparing fluorescent probes for microarray studies. Methods Mol Biol 224:55-60
Mezey, Eva; Parmalee, Alissa; Szalayova, Ildiko et al. (2003) Of splice and men: what does the distribution of IKAP mRNA in the rat tell us about the pathogenesis of familial dysautonomia? Brain Res 983:209-14
Wijsman, E M; Rosenthal, E A; Hall, D et al. (2003) Genome-wide scan in a large complex pedigree with predominantly male schizophrenics from the island of Kosrae: evidence for linkage to chromosome 2q. Mol Psychiatry 8:695-705, 643
Xiang, Charlie C; Brownstein, Michael J (2003) Fabrication of cDNA microarrays. Methods Mol Biol 224:1-7
Witmer, Philip D; Doheny, Kimberly F; Adams, Marcia K et al. (2003) The development of a highly informative mouse Simple Sequence Length Polymorphism (SSLP) marker set and construction of a mouse family tree using parsimony analysis. Genome Res 13:485-91
Xiang, C C; Chen, M; Kozhich, O A et al. (2003) Probe generation directly from small numbers of cells for DNA microarray studies. Biotechniques 34:386-8, 390, 392-3
Xiang, Charlie C; Chen, Mei; Ma, Li et al. (2003) A new strategy to amplify degraded RNA from small tissue samples for microarray studies. Nucleic Acids Res 31:e53
Tran, Simon D; Pillemer, Stanley R; Dutra, Amalia et al. (2003) Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet 361:1084-8

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