Abstract

The goal of this protocol is to use a targeted serotonergic manipulation (tryptophan depletion) and specific neurocognitive and neuroimaging paradigms to consider the role of serotonin in emotional processing. In particular, we will evaluate claims that serotonin has a role in the effective processing of aversive signals. In addition, we will examine whether tryptophan depletion will attenuate the neural response to aversive material.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002862-01
Application #
7137923
Study Section
(DIRP)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Mitchell, Derek G V; Luo, Qian; Avny, Shelley B et al. (2009) Adapting to dynamic stimulus-response values: differential contributions of inferior frontal, dorsomedial, and dorsolateral regions of prefrontal cortex to decision making. J Neurosci 29:10827-34
Finger, Elizabeth C; Marsh, Abigail A; Buzas, Beata et al. (2007) The impact of tryptophan depletion and 5-HTTLPR genotype on passive avoidance and response reversal instrumental learning tasks. Neuropsychopharmacology 32:206-15
Marsh, Abigail A; Finger, Elizabeth C; Buzas, Beata et al. (2006) Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion. Psychopharmacology (Berl) 189:387-94