The experiments performed here are currently based on the hypothesis that oxygen radicals generated as a result of central nervous systems (CNS) injury and/or ischemia contribute to pathogenesis, at least in part, by altering endothelial membrane integrity. Due to the limited availability of cultured cerebrovascular endothelial cells (EC) which constitute the blood-brain barrier (BBB), only a minimal number of experiments were able to be performed under this project title. However, these experiments demonstrated that oxygen free radicals such as superoxide anion (.O2-) and hydroxyl (OH-) generated by EC may be responsible for alterations in BBB permeability known to occur in neuropathologic disorders such as stroke.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002324-16
Application #
3782326
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
1993
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code