Abstract

Capillary endothelial cells derived from human brain (HBCEC) synthesize prostaglandin D2 (PGD2) which can be stimulated, among other prostanoids, by endothelin 1 (ET-1). Exogenous PGD2 dose-dependently augmented the production of vasoconstrictive prostaglandin F2alpha (PGF2alpha), 9alpha- 11-beta prostaglandin F2 (9alpha-11-beta PGF2), and thromboxane B2 (TxB2) and vasodilatory prostaglandin E2 (PGE2) as well as cAMP by HBCEC. These results suggest that PGD2 may play a role in cerebral capillaries under physiologic and pathologic conditions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002777-04
Application #
3846254
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
National Institute of Neurological Disorders and Stroke
Department
Type
DUNS #
City
State
Country
United States
Zip Code