We are performing case-control studies within a population-based registry of children with cerebral palsy (CP) born between 1983-1985 in four northern California counties. Work during FY97 included: (a) a study of maternal infection as an important risk factor for CP in infants of normal birthweight, published as the lead article in J.A.M.A. with an accompanying editorial; (b) a paper on potential asphyxiating complications and their association with spastic CP, paper submitted; (c) major new case- control study of CP in very low birthweight infants born in northern California in 1988, with data analysis ready to begin; (d) a study in preparation of transient neonatal hypothyroxinemia in term and near-term infants, finding that low T4 in the first days of life is associated with the risk of CP; (e) publications on determination of gestational age and on what placentas are submitted for pathologic examination; a paper in press on magnesium and neonatal mortality; and papers submitted on potentially asphyxiating conditions and CP, and on the reliability of histologic study of the placental; (f) with Dr. T.M. Phillips of George Washington University, and Dr. J.M. Dambrosia (BFSB), a study of ultramicroassay of blood constituents in newborn infants later recognized to have CP and controls.
| Hankins, Gary D V; MacLennan, Alastair H; Speer, Michael E et al. (2006) Obstetric litigation is asphyxiating our maternity services. Obstet Gynecol 107:1382-5 |
| Nelson, Karin B; Leviton, Alan (2006) Hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 354:1643-5; author reply 1643-5 |
| Lynch, John Kylan; Han, Christina J; Nee, Linda E et al. (2005) Prothrombotic factors in children with stroke or porencephaly. Pediatrics 116:447-53 |
| Wu, Yvonne W; Lynch, John K; Nelson, Karin B (2005) Perinatal arterial stroke: understanding mechanisms and outcomes. Semin Neurol 25:424-34 |
| Nelson, Karin B (2005) Neonatal encephalopathy: etiology and outcome. Dev Med Child Neurol 47:292 |
| Nelson, Karin B; Dambrosia, James M; Iovannisci, David M et al. (2005) Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatr Res 57:494-9 |
| Nelson, Karin B; Lynch, John K (2004) Stroke in newborn infants. Lancet Neurol 3:150-8 |
| Grether, Judith K; Nelson, Karin B; Walsh, Eileen et al. (2003) Intrauterine exposure to infection and risk of cerebral palsy in very preterm infants. Arch Pediatr Adolesc Med 157:26-32 |
| Nelson, Karin B (2003) Can we prevent cerebral palsy? N Engl J Med 349:1765-9 |
| Lynch, John Kylan; Hirtz, Deborah G; DeVeber, Gabrielle et al. (2002) Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics 109:116-23 |
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