Low-intensity DC polarization of focal cortical areas is known to alter the function of neurons in animals and humans. We are investigating the properties of this kind of brain stimulation and testing its ability to alter cognitive function in healthy subjects. We have completed a large Phase I, sham-controlled trial of DC polarization of the left prefrontal area in healthy volunteers. Results show safety even at higher intensities than those used in published modern studies and we also found a significant facilitation of word list generation with anodal current relative to sham and cathodal current. Recently acquired pilot data suggest similar effects of anodal current on impaired fluency in patients with frontotemporal dementia. We are now conducting a larger, double-blind trail in frontotemporal dementia, looking at a range of behavioral measures.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002977-07
Application #
7143889
Study Section
(BSU)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2005
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code
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