Calorimetry is a sensitive biophysical technique that allows investigation into polymerizations, conformational changes, phase transitions, and other molecular interactions. Patented conduction calorimetry is being applied to collaborative research projects with both NIH intramural and extramural scientists. Two research prototype instruments, for simultaneous heat capacity and thermal conductivity measurements, are being evaluated for further development and applications. A specific instrumentation aim is to improve the usability of these instruments by updating the operating systems, the data collection subsystem, and the calibration and data analysis subsystems. Existing biomedical research collaborations include application of calorimetric methods for studying collagen fiber structure and function (NICHD), thermodynamic properties of membrane liposomes (NIAMS), and actin polymerization (University of Maryland).

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Intramural Research (Z01)
Project #
1Z01OD011042-02
Application #
6548681
Study Section
(BEPS)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Office of the Director, NIH
Department
Type
DUNS #
City
State
Country
United States
Zip Code