Photodynamic therapy (PDT), which is the interaction of light with hematoporphyrin derivative (HPD or Photofrin II), is in clinical use in several areas of application. Currently, PDT is being used clinically for bronchial obstructions, carcinoma in situ of the bladder, and intraperitoneal and pleural tumors. Specially designed and constructed fiber-optic probes and introducers are modified on a case-by-case basis and calibrated in terms of irradiance delivered to the tissue. Calibrated custom photodiodes are placed at strategic locations within the cavity to provide a dosimetry record and irradiance values (see project Z01 RR 10272-05). Dosimetry for PDT is complex, due to the variable irradiation levels within the tissue, the sequestering of HPD, and tissue oxygenation.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Intramural Research (Z01)
Project #
1Z01RR010214-08
Application #
3852922
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost
Name
National Center for Research Resources
Department
Type
DUNS #
City
State
Country
United States
Zip Code