Experimental evidence indicates that the efficacy of photodynamic therapy (PDT) is temperature-dependent. This opens the possibility of using a temperature gradient in the tissue to partially compensate for the rapid attenuation of light, thus allowing effective treatment to a greater depth. By pulsing the surface temperature at an appropriate rate and illuminating only during the cool phase, the treatment at a selected depth will occur during the warm phase, due to the propagation delay experienced by the temperature wave.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Intramural Research (Z01)
Project #
1Z01RR010314-03
Application #
3874187
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
National Center for Research Resources
Department
Type
DUNS #
City
State
Country
United States
Zip Code