All N:NIH(S)-B mice examined have multiple foci of hepatic necrosis and inflammation. The cause of this hepatitis is unknown. This strain was developed at the NIH Animal Genetic Resource for use as foster mothers in the barrier facility. All mice appear clinically normal, but have significant abnormalities in their livers. Numerous studies are in progress to determine the etiology and to explore the pathogenesis of hepatitis in this strain. Vitamin A is being examined as a possible etiology or co-factor. Mouse strains closely related to the N:NIH(S)-B are being examined for hepatic abnormalities. Hepatitis in this strain may serve as a useful model to study the pathogenesis of hepatitis in animals and humans.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Intramural Research (Z01)
Project #
1Z01RR010400-03
Application #
3767472
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
National Center for Research Resources
Department
Type
DUNS #
City
State
Country
United States
Zip Code