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Takamatsu, Yuki; Das, Debananda; Kohgo, Satoru et al. (2018) The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase. Cell Chem Biol 25:1268-1278.e3
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Ghosh, Arun K; Gemma, Sandra; Baldridge, Abigail et al. (2008) Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies. J Med Chem 51:6021-33
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Ghosh, Arun K; Chapsal, Bruno D; Weber, Irene T et al. (2008) Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance. Acc Chem Res 41:78-86
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Maeda, Kenji; Das, Debananda; Yin, Philip D et al. (2008) Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition. J Mol Biol 381:956-74
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Nakata, Hirotomo; Steinberg, Seth M; Koh, Yasuhiro et al. (2008) Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs. Antimicrob Agents Chemother 52:2111-9
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Mitsuya, Hiroaki; Maeda, Kenji; Das, Debananda et al. (2008) Development of protease inhibitors and the fight with drug-resistant HIV-1 variants. Adv Pharmacol 56:169-97
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Amano, Masayuki; Koh, Yasuhiro; Das, Debananda et al. (2007) A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother 51:2143-55
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Koh, Yasuhiro; Matsumi, Shintaro; Das, Debananda et al. (2007) Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. J Biol Chem 282:28709-20
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Harada, Shigeyoshi; Hazra, Rohan; Tamiya, Sadahiro et al. (2007) Emergence of human immunodeficiency virus type 1 variants containing the Q151M complex in children receiving long-term antiretroviral chemotherapy. Antiviral Res 75:159-66
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Nakata, Hirotomo; Amano, Masayuki; Koh, Yasuhiro et al. (2007) Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Antimicrob Agents Chemother 51:2701-8
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Showing the most recent 10 out of 51 publications
