""""""""DISCONTINUED This is a pilot study designed to evaluate the efficacy and toxicity of a five-day infusion of paclitaxel concurrent with radiation therapy for advanced head and neck cancers. Patients with previously untreated stage III and IV squamous cell cancer of the oral cavity, oropharynx, hypopharynx, larynx, and maxillary sinus as well as stage II squamous cell cancers of the base of tongue and maxillary sinus are eligible. Tolerance of the regimen will be evaluated by using RTOG and CTEP standard toxicity criteria and by median elapsed treatment time. Serial tumors will be obtained to measure tumor potential doubling time and biological effects of treatment on the cell cycle."""""""" Nineteen patients have been treated thus far. Six patients have had pre and post-paclitaxel biopsies. Accrual ceiling is 30 patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC007231-04
Application #
6163427
Study Section
Special Emphasis Panel (RO)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
National Cancer Institute Division of Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code