We will study the differences in cellular protein expression between normal and tumoral kidney tissues as well as the profile of protein expression in different tumor types of renal neplasms, using proteomics technology. The continuation of this line of work will hopefully lead to the discovery of new molecular markers important in the diagnosis and treatment of renal cancer. We will develop techniques that assist in the identification of proteins in paraffin-fixed tissues. Comparison analyses will be performed using frozen tissues.
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| Wei, M-H; Toure, O; Glenn, G M et al. (2006) Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. J Med Genet 43:18-27 |
| Torres-Cabala, Carlos; Bibbo, Marluce; Panizo-Santos, Angel et al. (2006) Proteomic identification of new biomarkers and application in thyroid cytology. Acta Cytol 50:518-28 |
| Schmidt, Laura S; Nickerson, Michael L; Warren, Michelle B et al. (2005) Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dube syndrome. Am J Hum Genet 76:1023-33 |
| Pak, Ho; Gourgiotis, Loukas; Chang, Wen-I et al. (2003) Role of metastasectomy in the management of thyroid carcinoma: the NIH experience. J Surg Oncol 82:10-8 |
