Abstract

Transmission electron microscopy (EM) is used as an adjunct procedure in the diagnosis of a wide range of neoplastic and non neoplastic diseases and can be extremely useful in well chosen diagnostic dilemmas. The main objectives of the diagnostic EM service are: (1) to provide high quality EM diagnostic services to NCI- and NIH-supported clinical diagnostic and treatment protocols (2) to help elucidate the pathogenesis of disease processes studied in these protocols (3) to teach pathology residents and fellows the application of EM in the diagnosis of human diseases and (4) to provide electron microscopic expertise to the NIH scientific community. The last year's accomplishments are summarized below: (1) A total of 100 patient tissues were processed and diagnosed by EM. The service is regularly inspected and certified by CAP. (2) Research specimens with multiple samples per specimen were processed and evaluated, resulting in 7 publications. (3) Invitation by the Society of Ultrastructural Pathology to lecture in the society's companion meeting on """"""""the routine use of electron microscopy and other adjunct diagnostic techniques in pediatric neoplasms"""""""" (US-CAP meeting, Chicago, Feb. 24, 2002)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Clinical Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC009394-08
Application #
6558556
Study Section
(LP)
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Martin-Manso, Gema; Galli, Susana; Ridnour, Lisa A et al. (2008) Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Res 68:7090-9
Lodish, Maya B; Powell, Anathea C; Abu-Asab, Mones et al. (2008) Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. J Clin Endocrinol Metab 93:1123-8
Lee, In Hye; Cao, Liu; Mostoslavsky, Raul et al. (2008) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A 105:3374-9
Yang, Youfeng; Padilla-Nash, Hesed M; Vira, Manish A et al. (2008) The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dube gene pathway. Cancer Genet Cytogenet 180:100-9
Valencia, Julio C; Rouzaud, Francois; Julien, Sylvain et al. (2007) Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. J Biol Chem 282:11266-80
Alesci, Salvatore; Perera, Shiromi M; Lai, Edwin W et al. (2007) Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevance. Endocrinology 148:3900-7
Isenberg, Jeff S; Hyodo, Fuminori; Matsumoto, Ken-Ichiro et al. (2007) Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation. Blood 109:1945-52
Steel, Jason C; Cavanagh, Heather M A; Burton, Mark A et al. (2007) Increased tumor localization and reduced immune response to adenoviral vector formulated with the liposome DDAB/DOPE. Eur J Pharm Sci 30:398-405
Isenberg, Jeff S; Romeo, Martin J; Abu-Asab, Mones et al. (2007) Increasing survival of ischemic tissue by targeting CD47. Circ Res 100:712-20
Schiffmann, Raphael; Rapkiewicz, Amy; Abu-Asab, Mones et al. (2006) Pathological findings in a patient with Fabry disease who died after 2.5 years of enzyme replacement. Virchows Arch 448:337-43

Showing the most recent 10 out of 23 publications