Abstract

The Neuro-Oncology Branch Laboratory of translational science is divided into three major areas:Project 1: Identification of Potential Molecular Targets in Gliomas and the Translation of These Findings into New Therapies for Patients with Malignant Gliomas Project 2: Exploration of the Translational/Therapeutic Potential of Stem Cell Biology in Gliomas Project 3: The Glioma Molecular Diagnostic Initiative (GMDI).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Clinical Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC010100-06
Application #
7292071
Study Section
(NOB)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Sun, Lixin; Hui, Ai-Min; Su, Qin et al. (2006) Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 9:287-300
De Roos, Anneclaire J; Rothman, Nathaniel; Brown, Merideth et al. (2006) Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. Neuro Oncol 8:145-55
Kotliarov, Yuri; Steed, Mary Ellen; Christopher, Neil et al. (2006) High-resolution global genomic survey of 178 gliomas reveals novel regions of copy number alteration and allelic imbalances. Cancer Res 66:9428-36
Wen, Patrick Y; Yung, W K Alfred; Lamborn, Kathleen R et al. (2006) Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 12:4899-907
Prados, Michael D; Lamborn, Kathleen; Yung, W K A et al. (2006) A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study. Neuro Oncol 8:189-93
Lee, Jeongwu; Kotliarova, Svetlana; Kotliarov, Yuri et al. (2006) Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9:391-403
Fine, Howard A (2005) Radiotherapy plus adjuvant temozolomide for the treatment of glioblastoma--a paradigm shift. Nat Clin Pract Oncol 2:334-5
Cho, Steve Y; Ravasi, Laura; Szajek, Lawrence P et al. (2005) Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma. J Nucl Med 46:1923-30
Brem, Steven S; Bierman, Philip J; Black, Peter et al. (2005) Central nervous system cancers: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 3:644-90
Camphausen, Kevin; Cerna, David; Scott, Tamalee et al. (2005) Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid. Int J Cancer 114:380-6

Showing the most recent 10 out of 14 publications