This project focuses upon the discovery of novel, naturally occurring antiviral and antitumor molecules from aqueous and organic solvent extracts of terrestrial plants, marine plants, animals and microorganisms. The research employs bioassay-guided isolation and characterization of active molecules. High-throughput screens to support this process are developed with a focus on critical molecular targets or processes implicated in viral (HIV) or cancer pathogenesis. Peptidic or proteinaceous leads are of interest, as well as non-peptic """"""""small-molecules."""""""" Structural elucidation involves use of multiple state-of-the-art technologies including mass spectrometry, NMR, and crystallography. New leads are studied in detail in collaboration with intramural and extramural investigators. Commercial partners are sought as soon as possible to participate in and support the preclinical and clinical development of the most promising leads.

Agency
National Institute of Health (NIH)
Institute
Division of Clinical Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC010369-01
Application #
6557464
Study Section
(MTDD)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code