Caloric restriction (CR: reducing caloric intake 30-40 percent below ad libitum levels) has been repeatedly shown to extend lifespan, reduce the incidence and delay the onset of age-related disease, enhance stress protection, and attenuate functional decline in mammals. The NIA longitudinal study of CR and aging in rhesus monkeys is in its 32nd year and 16% of the animals remain on study. In 2012, we reported findings of improved health; however, unlike findings from a similar study at the University of Wisconsin, the NIA CR monkeys did not have improved survival compared to the controls. In 2017, we compared the study designs and outcomes concluding that aging is malleable in primates and a reasonable target for intervention. Both studies are on-going, and we will continue to monitor the monkeys for age-related changes in many health parameters. Monkeys are currently tested on learning and memory tasks. Additionally, tissue and serum are used to assess biomarkers of aging.
| Mattison, Julie A; Colman, Ricki J (2018) Response to Le Bourg. J Gerontol A Biol Sci Med Sci 73:310 |
| Vaughan, Kelli L; Mattison, Julie A (2018) Watch the Clock, Not the Scale. Cell Metab 27:1159-1160 |
| Mattison, Julie A; Vaughan, Kelli L (2017) An overview of nonhuman primates in aging research. Exp Gerontol 94:41-45 |
| Aghazadeh-Sanai, Nona; Downs, Jodi L; Mattison, Julie A et al. (2017) Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques. Neurobiol Aging 55:213-216 |
| Balasubramanian, Priya; Mattison, Julie A; Anderson, Rozalyn M (2017) Nutrition, metabolism, and targeting aging in nonhuman primates. Ageing Res Rev 39:29-35 |
| Mattison, Julie A; Colman, Ricki J; Beasley, T Mark et al. (2017) Caloric restriction improves health and survival of rhesus monkeys. Nat Commun 8:14063 |
| Di Biase, Stefano; Lee, Changhan; Brandhorst, Sebastian et al. (2016) Fasting-Mimicking Diet Reduces HO-1 to Promote TÂ Cell-Mediated Tumor Cytotoxicity. Cancer Cell 30:136-146 |
| Sitzmann, Brandon D; Brown, Donald I; Garyfallou, Vasilios T et al. (2014) Impact of moderate calorie restriction on testicular morphology and endocrine function in adult rhesus macaques (Macaca mulatta). Age (Dordr) 36:183-97 |
| Urbanski, Henryk F; Mattison, Julie A; Roth, George S et al. (2013) Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies. Exp Gerontol 48:1136-9 |
| Mercken, Evi M; Majounie, Elisa; Ding, Jinhui et al. (2013) Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction. Aging (Albany NY) 5:692-703 |
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