During FY15 we accomplished the following: 1) We carried out time-dependent activation of primary mouse neurons with TNFa; and IL-1b;, prepared RNA, and assayed changes in gene expression by microarray analyses. 2) We extended studies with human neuronal cell lines to assay NF-kB;B induction in response to TNFa; and IL-1b;, and gene expression changes that accompany inflammatory stimulation. 3) we carried out kinetic analyses of NF-kB translocation in neuronal cell lines in response to TNFa and IL-1b stimulation
| Sen, Ranjan (2011) The origins of NF-?B. Nat Immunol 12:686-8 |
| Munk, Rachel B; Sugiyama, Katsuki; Ghosh, Paritosh et al. (2011) Antigen-independent IFN-? production by human naïve CD4 T cells activated by IL-12 plus IL-18. PLoS One 6:e18553 |
| Olkhanud, Purevdorj B; Damdinsuren, Bazarragchaa; Bodogai, Monica et al. (2011) Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4? T cells to T-regulatory cells. Cancer Res 71:3505-15 |
