Claudin 7 knockdown revealed gene expression patturns that implicated its role several pathways including cell cycle, proliferation and death as well as cell migration. Since these pathways are extremely relevant to cancer progression and metastsis, we investigated these further. After using various methods such as we concluded that claudin-7 provided contributed in increased invasion but interestingly decreased migration. It would be fascinating to further tease out the role of of claudin 7 in these two tightly regulated and entwined mechanisms
| Dahiya, Neetu; Becker, Kevin G; Wood 3rd, William H et al. (2011) Claudin-7 is frequently overexpressed in ovarian cancer and promotes invasion. PLoS One 6:e22119 |
| Ramalingam, Arivudainambi; Wang, Xuexuan; Gabello, Melissa et al. (2010) Dietary Methionine Restriction Improves Colon Tight Junction Barrier Function and Alters Claudin Expression Pattern. Am J Physiol Cell Physiol : |
| Lal-Nag, Madhu; Morin, Patrice J (2009) The claudins. Genome Biol 10:235 |
| Li, Jianghong; Sherman-Baust, Cheryl A; Tsai-Turton, Miyun et al. (2009) Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer. BMC Cancer 9:244 |
| D'Souza, Theresa; Sherman-Baust, Cheryl A; Poosala, Suresh et al. (2009) Age-related changes of claudin expression in mouse liver, kidney, and pancreas. J Gerontol A Biol Sci Med Sci 64:1146-53 |
