Life Course Epidemiology in the British 1946 Birth Cohort Study

Guralnik, Jack M.

Abstract

The study's health measures in adult life have been concentrated on cardiovascular, respiratory, mental and musculoskeletal health, cognitive function, and a study of transition through the menopause, all topics of relevance and importance to NIA. State of health and change of function with age has been measured in these areas, and pathways to those states and changes have been studied using the data from birth to mid-life. This cohort offers a unique opportunity to evaluate how the life course affects various aging outcomes.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAAG001057-02
• Application #: 7964157
• Support Year: 2
• Fiscal Year: 2009
• Total Cost: $350,898

Institution

• Name: National Institute on Aging

Publications

Strand, Bjorn Heine; Kuh, Diana; Shah, Imran et al. (2012) Childhood, adolescent and early adult body mass index in relation to adult mortality: results from the British 1946 birth cohort. J Epidemiol Community Health 66:225-32

Strand, Bjorn Heine; Mishra, Gita; Kuh, Diana et al. (2011) Smoking history and physical performance in midlife: results from the British 1946 birth cohort. J Gerontol A Biol Sci Med Sci 66:142-9

Murray, Emily T; Mishra, Gita D; Kuh, Diana et al. (2011) Life course models of socioeconomic position and cardiovascular risk factors: 1946 birth cohort. Ann Epidemiol 21:589-97

Strand, Bjørn Heine; Cooper, Rachel; Hardy, Rebecca et al. (2011) Lifelong socioeconomic position and physical performance in midlife: results from the British 1946 birth cohort. Eur J Epidemiol 26:475-83

Tom, Sarah E; Cooper, Rachel; Kuh, Diana et al. (2010) Fetal environment and early age at natural menopause in a British birth cohort study. Hum Reprod 25:791-8

Tom, Sarah E; Kuh, Diana; Guralnik, Jack M et al. (2010) Self-reported sleep difficulty during the menopausal transition: results from a prospective cohort study. Menopause :

Hardy, Rebecca; Cooper, Rachel; Shah, Imran et al. (2010) Is chair rise performance a useful measure of leg power? Aging Clin Exp Res 22:412-8

Guralnik, Jack M; Butterworth, Suzanne; Patel, Kushang et al. (2009) Reduced midlife physical functioning among never married and childless men: evidence from the 1946 British birth cohort study. Aging Clin Exp Res 21:174-81

Kuh, Diana; Cooper, Rachel; Hardy, Rebecca et al. (2009) Lifetime cognitive performance is associated with midlife physical performance in a prospective national birth cohort study. Psychosom Med 71:38-48

Cooper, Rachel; Mishra, Gita; Clennell, Suzie et al. (2008) Menopausal status and physical performance in midlife: findings from a British birth cohort study. Menopause :