Studies on Arthropod Vectors of Disease

Gwadz, Robert

Abstract

MALI During FY 14 Dr. Gwadz has been working with the LMVR entomology team at the MRTC in Bamako to provide support for the LMIV vaccine trials in Mali. The MRTC insectaries have been modified and upgraded to maximize mosquito rearing. Additional changes have set up secure areas for holding infected mosquitoes and area for mosquito dissection. Mosquito rearing protocols have been significantly improved to maximize adult survival, feeding avidity and susceptibility to infection. Vaccine trials are currently underway. CAMBODIA During FY 14, the NIH laboratories in Cambodia were required to move from there initial location at the centrally located Nationl Malaria Center,CNM,to a new facilty located at the edge of Phnom Penh. The new CNM building is well designed. The new NIH laboratories have suffiucient space and can permit research expansion. New insectaries will be completed before the end of the year. The new NIH/LMVR malaria laboratories are now among the best in the region and the insectaries shouls serve as models for research efficiecy. The location of the new CNM is very inconvenient. How this location will affect staff retention is yet to be determined.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAAI000629-23
• Application #: 8946291
• Support Year: 23
• Fiscal Year: 2014

Institution

• Name: Niaid Extramural Activities

Publications

Murphy, Jittawadee R; Weiss, Walter R; Fryauff, David et al. (2014) Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies. Malar J 13:215

Dieter, Kathryne L; Huestis, Diana L; Lehmann, Tovi (2012) The effects of oviposition-site deprivation on Anopheles gambiae reproduction. Parasit Vectors 5:235

Yaro, Alpha S; Traoré, Adama I; Huestis, Diana L et al. (2012) Dry season reproductive depression of Anopheles gambiae in the Sahel. J Insect Physiol 58:1050-9

Butail, Sachit; Manoukis, Nicholas; Diallo, Moussa et al. (2012) Reconstructing the flight kinematics of swarming and mating in wild mosquitoes. J R Soc Interface 9:2624-38

Huestis, Diana L; Yaro, Alpha S; Traore, Adama I et al. (2012) Seasonal variation in metabolic rate, flight activity and body size of Anopheles gambiae in the Sahel. J Exp Biol 215:2013-21

Maiga, Hamidou; Dabire, Roch K; Lehmann, Tovi et al. (2012) Variation in energy reserves and role of body size in the mating system of Anopheles gambiae. J Vector Ecol 37:289-97

Diabate, Abdoulaye; Yaro, Alpha S; Dao, Adama et al. (2011) Spatial distribution and male mating success of Anopheles gambiae swarms. BMC Evol Biol 11:184

Butail, Sachit; Manoukis, Nicholas; Diallo, Moussa et al. (2011) 3D tracking of mating events in wild swarms of the malaria mosquito Anopheles gambiae. Conf Proc IEEE Eng Med Biol Soc 2011:720-3

Huestis, Diana L; Yaro, Alpha S; Traore, Adama I et al. (2011) Variation in metabolic rate of Anopheles gambiae and A. arabiensis in a Sahelian village. J Exp Biol 214:2345-53

Hume, Jen C C; Hamilton 3rd, Howard; Lee, Kevin L et al. (2011) Susceptibility of Anopheles stephensi to Plasmodium gallinaceum: a trait of the mosquito, the parasite, and the environment. PLoS One 6:e20156