Abstract

In HIV-infected patients treated with HAART, there are variable rates of reconstitution of T cell numbers and function. An understanding of the mechanisms underlying the recovery of T cells will be important for the design of future strategies to improve T cell reconstitution. The thymus is the organ responsible for producing new naive T cells with a broad immune repertoire from bone marrow-derived precursors. IL-7 is a cytokine that has direct effects upon the thymus and naive T cells. This study examines the role of the thymus in HIV infection and immune reconstitution, and how IL-7 can affect that role.This study seeks to improve our understanding of how HAART affects the immune response to HIV, and how therapeutic vaccination, with or without additional interventions, will lead to improved immunity against HIV and better control of virus replication.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI005013-11
Application #
8556089
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2012
Total Cost
$1,273,879
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Adams, William C; Bond, Emily; Havenga, Menzo J E et al. (2009) Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN. J Gen Virol 90:1600-10
Sun, Yue; Bailer, Robert T; Rao, Srinivas S et al. (2009) Systemic and mucosal T-lymphocyte activation induced by recombinant adenovirus vaccines in rhesus monkeys. J Virol 83:10596-604
Koup, Richard A; Lamoreaux, Laurie; Zarkowsky, David et al. (2009) Replication-defective adenovirus vectors with multiple deletions do not induce measurable vector-specific T cells in human trials. J Virol 83:6318-22
Cecchinato, Valentina; Tryniszewska, Elzbieta; Ma, Zhong Min et al. (2008) Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection. J Immunol 180:5439-47
Precopio, Melissa L; Butterfield, Tiffany R; Casazza, Joseph P et al. (2008) Optimizing peptide matrices for identifying T-cell antigens. Cytometry A 73:1071-8