In this fiscal year, we completed numerous clinical projects involving myositis patients. These projects included: (a) Analyzing a longitudinal cohort of pediatric myositis patients with anti-NT5C1a autoantibodies. Among other observations, this published study established that anti-NT5C1a autoantibodies are found in children with myositis and juvenile idiopathic arthritis. In children with myositis, anti-NT5C1a autoantibodies are associated with more severe disease. (b) Studying the development of myositis in patients treated with immune checkpoint inhibitors. We published a study showing that pre-existing anti-acetylcholine receptor autoantibodies and B cell lymphopaenia are associated with the development of myositis in patients with thymoma treated with avelumab, an immune checkpoint inhibitor targeting programmed death-ligand 1. (c) Defining unique phenotypes associated with distinct myositis autoantibodies. Using a longitudinal cohort of adult myositis patients, we published an paper showing that patients with anti-PM/Scl autoantibodies have a unique pattern of muscle involvement with prominent perivascular inflammation on muscle biopsy and proximal arm muscles weaker than proximal leg weakness on physical exam. These patients also have extensive extra-muscular manifestations including interstitial lung disease. In collaboration with Dr. Lisa Rider, Dr. Fred Miller, and their colleagues at NIEHS, we have sought to determine the phenotype of pediatric myositis patients with anti-Ro52 autoantibodies. We found that children with myositis who have anti-Ro52 autoantibodies are more likely to have interstitial lung disease. We have presented these findings at national meetings and are now preparing a manuscript for publication.

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Support Year
4
Fiscal Year
2018
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Name
Arthritis, Musculoskeletal, Skin Dis
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Pinal-Fernandez, Iago; Mammen, Andrew L (2018) Dermatomyositis etiopathogenesis: a rebel soldier in the muscle. Curr Opin Rheumatol 30:623-629
Yeker, Richard M; Pinal-Fernandez, Iago; Kishi, Takayuki et al. (2018) Anti-NT5C1A autoantibodies are associated with more severe disease in patients with juvenile myositis. Ann Rheum Dis 77:714-719
Selva-O'Callaghan, Albert; Pinal-Fernandez, Iago; Trallero-Araguás, Ernesto et al. (2018) Classification and management of adult inflammatory myopathies. Lancet Neurol 17:816-828
Mammen, Andrew L; Rajan, Arun; Pak, Katherine et al. (2018) Pre-existing antiacetylcholine receptor autoantibodies and B cell lymphopaenia are associated with the development of myositis in patients with thymoma treated with avelumab, an immune checkpoint inhibitor targeting programmed death-ligand 1. Ann Rheum Dis :
Mammen, Andrew L (2017) Which nonautoimmune myopathies are most frequently misdiagnosed as myositis? Curr Opin Rheumatol 29:618-622
Weihl, C C; Mammen, A L (2017) Sporadic inclusion body myositis - a myodegenerative disease or an inflammatory myopathy. Neuropathol Appl Neurobiol 43:82-91
Amici, David R; Pinal-Fernandez, Iago; Mázala, Davi A G et al. (2017) Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis. Acta Neuropathol Commun 5:24
Mohassel, Payam; Foley, A Reghan; Donkervoort, Sandra et al. (2017) Anti-3-hydroxy-3-methylglutaryl-coenzyme a reductase necrotizing myopathy masquerading as a muscular dystrophy in a child. Muscle Nerve :
Albayda, Jemima; Pinal-Fernandez, Iago; Huang, Wilson et al. (2017) Antinuclear Matrix Protein 2 Autoantibodies and Edema, Muscle Disease, and Malignancy Risk in Dermatomyositis Patients. Arthritis Care Res (Hoboken) 69:1771-1776
Pinal-Fernandez, Iago; Casal-Dominguez, Maria; Carrino, John A et al. (2017) Thigh muscle MRI in immune-mediated necrotising myopathy: extensive oedema, early muscle damage and role of anti-SRP autoantibodies as a marker of severity. Ann Rheum Dis 76:681-687

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