In this fiscal year, we completed numerous clinical projects involving myositis patients. These projects included: (a) Analyzing a longitudinal cohort of pediatric myositis patients with anti-NT5C1a autoantibodies. Among other observations, this published study established that anti-NT5C1a autoantibodies are found in children with myositis and juvenile idiopathic arthritis. In children with myositis, anti-NT5C1a autoantibodies are associated with more severe disease. (b) Studying the development of myositis in patients treated with immune checkpoint inhibitors. We published a study showing that pre-existing anti-acetylcholine receptor autoantibodies and B cell lymphopaenia are associated with the development of myositis in patients with thymoma treated with avelumab, an immune checkpoint inhibitor targeting programmed death-ligand 1. (c) Defining unique phenotypes associated with distinct myositis autoantibodies. Using a longitudinal cohort of adult myositis patients, we published an paper showing that patients with anti-PM/Scl autoantibodies have a unique pattern of muscle involvement with prominent perivascular inflammation on muscle biopsy and proximal arm muscles weaker than proximal leg weakness on physical exam. These patients also have extensive extra-muscular manifestations including interstitial lung disease. In collaboration with Dr. Lisa Rider, Dr. Fred Miller, and their colleagues at NIEHS, we have sought to determine the phenotype of pediatric myositis patients with anti-Ro52 autoantibodies. We found that children with myositis who have anti-Ro52 autoantibodies are more likely to have interstitial lung disease. We have presented these findings at national meetings and are now preparing a manuscript for publication.

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4
Fiscal Year
2018
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Name
Arthritis, Musculoskeletal, Skin Dis
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Pinal-Fernandez, Iago; Mammen, Andrew L (2018) Dermatomyositis etiopathogenesis: a rebel soldier in the muscle. Curr Opin Rheumatol 30:623-629
Yeker, Richard M; Pinal-Fernandez, Iago; Kishi, Takayuki et al. (2018) Anti-NT5C1A autoantibodies are associated with more severe disease in patients with juvenile myositis. Ann Rheum Dis 77:714-719
Selva-O'Callaghan, Albert; Pinal-Fernandez, Iago; Trallero-Araguás, Ernesto et al. (2018) Classification and management of adult inflammatory myopathies. Lancet Neurol 17:816-828
Mammen, Andrew L; Rajan, Arun; Pak, Katherine et al. (2018) Pre-existing antiacetylcholine receptor autoantibodies and B cell lymphopaenia are associated with the development of myositis in patients with thymoma treated with avelumab, an immune checkpoint inhibitor targeting programmed death-ligand 1. Ann Rheum Dis :
Pinal-Fernandez, Iago; Casal-Dominguez, Maria; Huapaya, Julio A et al. (2017) A longitudinal cohort study of the anti-synthetase syndrome: increased severity of interstitial lung disease in black patients and patients with anti-PL7 and anti-PL12 autoantibodies. Rheumatology (Oxford) 56:999-1007
Tiniakou, Eleni; Pinal-Fernandez, Iago; Lloyd, Thomas E et al. (2017) More severe disease and slower recovery in younger patients with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Rheumatology (Oxford) 56:787-794
Lloyd, Thomas E; Pinal-Fernandez, Iago; Michelle, E Harlan et al. (2017) Overlapping features of polymyositis and inclusion body myositis in HIV-infected patients. Neurology 88:1454-1460
Paik, Julie J; Wigley, Fredrick M; Shah, Ami A et al. (2017) Association of Fibrosing Myopathy in Systemic Sclerosis and Higher Mortality. Arthritis Care Res (Hoboken) 69:1764-1770
Aggarwal, Rohit; Rider, Lisa G; Ruperto, Nicolino et al. (2017) 2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheu Ann Rheum Dis 76:792-801
Aggarwal, Rohit; Rider, Lisa G; Ruperto, Nicolino et al. (2017) 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheu Arthritis Rheumatol 69:898-910

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