As a radiation oncologist with graduate and postdoctoral training in both cancer biology and general immunology, the ultimate goal of my research is to discover effective ways to combine immunotherapies (IT) with radiation therapy (RT) to promote systemic tumor control while achieving local tumor control. Toward this goal, I opened a clinical trial, NCT01449279, with Susan Knox at Stanford, prior to joining NCI. To support the development of RT + IT trials at NCI, and to build upon existing programmatic strengths of the NCI intramural program, I am collaborating with George Pavlakis (NCI/VB), Thomas Waldmann and Kevin Conlon (NCI/LMB) to test rIL-15 + RT and hetIL-15 + RT in preclinical models, and I am the primary ROB Associate Investigator working with Tim Greten and Austin Duffy (NCI/TGIB) on NCI's colorectal liver metastases (15-C-0021), and pancreas (15-C-0027) RT + IT studies. Ultimately, we plan to study EV subsets in responders and non-responders from immunotherapy trials (such as these RT + IT trials, NCI VB vaccine trials, and other tumor immunotherapy trials at NCI), to translate the EV subset signatures into biological information that could be used for personalized and adaptive treatments for our patients.
| Morales-Kastresana, Aizea; Jones, Jennifer C (2017) Flow Cytometric Analysis of Extracellular Vesicles. Methods Mol Biol 1545:215-225 |
| Mateescu, Bogdan; Kowal, Emma J K; van Balkom, Bas W M et al. (2017) Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper. J Extracell Vesicles 6:1286095 |
| Musich, Thomas; Jones, Jennifer C; Keele, Brandon F et al. (2017) Flow virometric sorting and analysis of HIV quasispecies from plasma. JCI Insight 2:e90626 |
| Nolan, John P; Jones, Jennifer C (2017) Detection of platelet vesicles by flow cytometry. Platelets 28:256-262 |
| Morales-Kastresana, Aizea; Telford, Bill; Musich, Thomas A et al. (2017) Labeling Extracellular Vesicles for Nanoscale Flow Cytometry. Sci Rep 7:1878 |
| Watson, Dionysios C; Bayik, Defne; Srivatsan, Avinash et al. (2016) Efficient production and enhanced tumor delivery of engineered extracellular vesicles. Biomaterials 105:195-205 |
| Danielson, Kirsty M; Estanislau, Jessica; Tigges, John et al. (2016) Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry. PLoS One 11:e0144678 |
| Crittenden, Marka; Kohrt, Holbrook; Levy, Ronald et al. (2015) Current clinical trials testing combinations of immunotherapy and radiation. Semin Radiat Oncol 25:54-64 |
| Fasola, Carolina E; Jones, Jennifer C; Huang, Derek D et al. (2013) Low-dose radiation therapy (2 Gy ýý 2) in the treatment of orbital lymphoma. Int J Radiat Oncol Biol Phys 86:930-5 |
| Parker, Jennifer J; Jones, Jennifer C; Strober, Samuel et al. (2013) Characterization of direct radiation-induced immune function and molecular signaling changes in an antigen presenting cell line. Clin Immunol 148:44-55 |
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