Abstract

This effort continues to be very productive as evidenced by the yearly publication output related to GVHD, including publication of the Branch initiated imatinib clinical trial. In addition, I have made several important contributions to the identification of novel skin manifestations of cGVHD, as well as identified the role of total body irradiation as a risk factor for cGVHD. Current projects including ssRNA analysis of cutaneous GVHD specimens to better understand the pathophysiology of skin disease. Clinical projects including the first topical study of ruxolitinib for skin GVHD and a case series on cutaneous calcinosis in skin GVHD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011549-06
Application #
10014723
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Goklemez, Sencer; Pirsl, Filip; Curtis, Lauren M et al. (2017) Clinical significance of IgE in a large cohort of patients with moderate or severe chronic graft-versus-host disease. Am J Hematol 92:E162-E164
Hakim, Frances T; Memon, Sarfraz; Jin, Ping et al. (2016) Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease. J Immunol 197:3490-3503
Imanguli, Matin M; Atkinson, Jane C; Mitchell, Sandra A et al. (2016) Erratum to ""Salivary Gland Involvement in Chronic Graft-versus-Host Disease: Prevalence, Clinical Significance, and Recommendations for Evaluation"" [Biol Blood Marrow Transplant 16:1362-1369]. Biol Blood Marrow Transplant 22:1147
Cowen, Edward West (2016) Graft-vs-Host Disease. JAMA Dermatol 152:356
Bassim, C W; Fassil, H; Mays, J W et al. (2015) Oral disease profiles in chronic graft versus host disease. J Dent Res 94:547-54
Jagasia, Madan H; Greinix, Hildegard T; Arora, Mukta et al. (2015) National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant 21:389-401.e1
Kuzmina, Zoya; Gounden, Verena; Curtis, Lauren et al. (2015) Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria. Am J Hematol 90:114-9
Zuo, Rena C; Naik, Haley B; Steinberg, Seth M et al. (2015) Risk factors and characterization of vitiligo and alopecia areata in patients with chronic graft-vs-host disease. JAMA Dermatol 151:23-32
Baird, Kristin; Comis, Leora E; Joe, Galen O et al. (2015) Imatinib mesylate for the treatment of steroid-refractory sclerotic-type cutaneous chronic graft-versus-host disease. Biol Blood Marrow Transplant 21:1083-90
Curtis, Lauren M; Datiles 3rd, Manuel B; Steinberg, Seth M et al. (2015) Predictive models for ocular chronic graft-versus-host disease diagnosis and disease activity in transplant clinical practice. Haematologica 100:1228-36

Showing the most recent 10 out of 14 publications