We have been mostly focusing on the analysis of the XFEL data that was collected in the past and made several fundamental discoveries. one of the most important results is the discovery of the mechanism of lattice phase transition triggered by ligand binding in a crystalline state. This mechanism is fundamental to the visualization of molecular movies. The results are being written in a manuscript. The XFEL beam at LCLS has been shut down for an upgrade for 2019 and will return to be operational in the middle of 2020.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011669-05
Application #
10014757
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Stagno, Jason R; Bhandari, Yuba R; Conrad, Chelsie E et al. (2017) Real-time crystallographic studies of the adenine riboswitch using an X-ray free-electron laser. FEBS J 284:3374-3380