The major goal of the NOB laboratory investigations is to develop novel experimental therapeutics, the most promising of which will hopefully be brought to the clinic to treat adults and children with incurable malignant brain tumors. The permeability of the blood-brain barrier (BBB) in a growing glioma is poorly understood. Independently, perfusion and enhancement of contrast agents have been the standard for measuring an open or closed BBB. With the use of in vitro studies and animal models, we can evaluate in real time, changes in BBB permeability with intratumoral microdialysis and imaging.
Our research aims to identify changes in drug concentrations and tumor dynamics as the invasive glioma progresses.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011686-04
Application #
10014765
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
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Country
Zip Code
Jackson, Sadhana; ElAli, Ayman; Virgintino, Daniela et al. (2017) Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer's disease. Neuro Oncol 19:1173-1182