Abstract

The microbiota is the entire community of microbes in a particular niche, such as the colon. The goal of the microbiota projects is to identify targets for cancer diagnosis or intervention through research on the microbiota of feces that has been prospectively and cost effectively collected from a general population of many thousands with essential covariate data and good ascertainment of cancer events. Compared to healthy people, we have identified significant alterations of the fecal microbiota in survivors of Hodgkin lymphoma and in people newly diagnosed with colorectal pre-cancer or postmenopausal breast cancer. Current efforts are to validate these associations and to examine whether the cancer-microbe associations are related to alterations immunity or inflammation, in levels or metabolism of hormones, or in small metabolites produced by the microbes or host.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010214-08
Application #
9549668
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Goedert, James J; Hua, Xing; Bielecka, Agata et al. (2018) Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota. Br J Cancer 118:471-479
Buchacz, Kate; Lau, Bryan; Jing, Yuezhou et al. (2016) Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010. J Infect Dis 214:862-72
Sinha, Rashmi; Ahn, Jiyoung; Sampson, Joshua N et al. (2016) Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One 11:e0152126
Vogtmann, Emily; Goedert, James J (2016) Epidemiologic studies of the human microbiome and cancer. Br J Cancer 114:237-42
Hua, Xing; Goedert, James J; Pu, Angela et al. (2016) Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine 3:172-179
Goedert, James J; Martin, Maureen P; Vitale, Francesco et al. (2016) Risk of Classic Kaposi Sarcoma With Combinations of Killer Immunoglobulin-Like Receptor and Human Leukocyte Antigen Loci: A Population-Based Case-control Study. J Infect Dis 213:432-8
An, Ping; Penugonda, Sudhir; Thorball, Christian W et al. (2016) Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia. PLoS Genet 12:e1005921
Cesar, Carina; Koethe, John R; Giganti, Mark J et al. (2016) Health outcomes among HIV-positive Latinos initiating antiretroviral therapy in North America versus Central and South America. J Int AIDS Soc 19:20684
Althoff, Keri N; Rebeiro, Peter F; Hanna, David B et al. (2016) A picture is worth a thousand words: maps of HIV indicators to inform research, programs, and policy from NA-ACCORD and CCASAnet clinical cohorts. J Int AIDS Soc 19:20707
Goedert, James J; Swenson, Luke C; Napolitano, Laura A et al. (2015) Risk of breast cancer with CXCR4-using HIV defined by V3 loop sequencing. J Acquir Immune Defic Syndr 68:30-5

Showing the most recent 10 out of 77 publications