Due to extremely severe cuts in budget and staffing, no progress was made on this research project during the reporting period. This is unfortunate, as this project had been - in previous years - one of our most productive research endeavors, resulting in a large number of publications in the peer-reviewed scientific literature. We are presently pursuing external research collaborations, especially with entities within the pharmaceutical industry, that may allow us to once again pursue this work and follow up on the promising findings that we had obtained in previous years on this project.

Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2017
Total Cost
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code
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Li, Xia; Xi, Zheng-Xiong; Markou, Athina (2013) Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology 66:12-23
Keck, Thomas M; Yang, Hong-Ju; Bi, Guo-Hua et al. (2013) Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl) 229:253-65
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Xi, Zheng-Xiong; Kiyatkin, Michael; Li, Xia et al. (2010) N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats. Neuropharmacology 58:304-13
Xi, Zheng-xiong; Spiller, Krista; Gardner, Eliot L (2009) Mechanism-based medication development for the treatment of nicotine dependence. Acta Pharmacol Sin 30:723-39

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