Our lab was first formed and functional in November, 2014. The summary includes only the activities since the lab became functional. Goal 1) examine and characterize both common and rare craniofacial anomalies through technologies including 3D imaging and genomic analysis to allow us to diagnosis, predict, and treat these conditions. We have collaborated with various clinical research teams to begin characterizing their patient cohorts for craniofacial and oral dysmorphology. We have initiated a Natural History Craniofacial Anomalies protocol that is awaiting final IRB approval. With this protocol in place, we will be conducting comprehensive assessments and analyses to correlate phenotype and genotype. Through these protocols, we are examining and comparing the craniofacial dysmorphologies across genetic mutations to understand the development of the facial and the influences that result in dysmorphologies. We are developing a craniofacial database that includes 3D imaging modalities. Goal 2) study bone regeneration to determine the mechanisms that distinguish bone regeneration in various environments. We have 1 approved small animal protocol that will allow further examination of bone marrow stromal/stem cell function in the various aging environments. We have a second small animal protocol that is undergoing approval that will examine a preclinical model of spontaneous bone regeneration and the influence of the aging environment. In each of these preclinical models, we are examining epigenetic variations and expression biomarkers.
| Di Gioia, Silvio Alessandro; Connors, Samantha; Matsunami, Norisada et al. (2017) A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome. Nat Commun 8:16077 |
| Young, Nathan M; Sherathiya, Krunal; Gutierrez, Luis et al. (2016) Facial surface morphology predicts variation in internal skeletal shape. Am J Orthod Dentofacial Orthop 149:501-8 |
| Sy, A A; Kim, W S; Chen, J et al. (2016) Acculturation levels and personalizing orthognathic surgery for the Asian American patient. Int J Oral Maxillofac Surg 45:1201-8 |
| Boyce, Alison M; Burke, Andrea; Cutler Peck, Carolee et al. (2016) Surgical Management of Polyostotic Craniofacial Fibrous Dysplasia: Long-Term Outcomes and Predictors for Postoperative Regrowth. Plast Reconstr Surg 137:1833-9 |
| Srour, Marissa K; Fogel, Jennifer L; Yamaguchi, Kent T et al. (2015) Natural large-scale regeneration of rib cartilage in a mouse model. J Bone Miner Res 30:297-308 |
| Yao, William; Bekmezian, Sona; Hardy, Dan et al. (2015) Cone-beam computed tomographic comparison of surgically assisted rapid palatal expansion and multipiece Le Fort I osteotomy. J Oral Maxillofac Surg 73:499-508 |
| Marchegiani, Shannon; Davis, Taylor; Tessadori, Federico et al. (2015) Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. Am J Hum Genet 97:99-110 |
| Chang, Michael K; Sears, Chad; Huang, John C et al. (2015) Correlation of Airway Volume With Orthognathic Surgical Movement Using Cone-Beam Computed Tomography. J Oral Maxillofac Surg 73:S67-76 |
| Peacock, Zachary S; Aghaloo, Tara; Bouloux, Gary F et al. (2014) Proceedings from the 2013 American Association of Oral and Maxillofacial Surgeons Research Summit. J Oral Maxillofac Surg 72:241-53 |
| Lee, Janice S; Collins, Michael T; Somerman, Martha J (2014) Partnerships in rare disorders. J Am Dent Assoc 145:694-5 |
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