Iron deficiency or overload syndromes are a major cause of pathology in billions of humans worldwide. While thalassemia syndromes are most commonly associated with iron overload, other anemias that result in ineffective erythropoiesis (myelodysplastic syndromes, sideroblastic anemia, congenital dyserythropoietic anemia, pernicious anemia) or require frequent transfusions (sickle cell syndromes, aplastic anemia) also manifest iron overload. Iron overload may also be caused by transfusional therapy and genetic mutation. As a result, the patients develop multiple endocrine abnormalities including diabetes, liver failure, heart failure, and bone pathology. An information-based approach was taken in our laboratory to identify erythroblast proteins that may be involved in this diseases process. Among candidate molecules, the cytokine named GDF15 was studied and determined to regulate iron via inhibition of hepcidin production. Additional studies have been performed to explore other candidate molecules and to develop novel insights into iron biology in humans.
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| Rabel, Antoinette; Leitman, Susan F; Miller, Jeffery L (2016) Ask about ice, then consider iron. J Am Assoc Nurse Pract 28:116-20 |
| Byrnes, Colleen; Lee, Y Terry; Meier, Emily R et al. (2016) Iron dose-dependent differentiation and enucleation of human erythroblasts in serum-free medium. J Tissue Eng Regen Med 10:E84-9 |
| Lee, Y Terry; de Vasconcellos, Jaira F; Byrnes, Colleen et al. (2015) Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts. PLoS One 10:e0144977 |
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| Miller, Jeffery L (2013) Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med 3: |
| Tanno, Toshihiko; Miller, Jeffery L (2011) [GDF15 expression and iron overload in ineffective erythropoiesis]. Rinsho Ketsueki 52:387-98 |
| Tanno, Toshihiko; Rabel, Antoinette; Alleyne, Michael et al. (2011) Hepcidin, anaemia, and prostate cancer. BJU Int 107:678-9 |
| Rivella, Stefano; Nemeth, Elizabeta; Miller, Jeffery Lynn (2010) Crosstalk between Erythropoiesis and Iron Metabolism. Adv Hematol 2010: |
| Tanno, Toshihiko; Miller, Jeffery L (2010) Iron Loading and Overloading due to Ineffective Erythropoiesis. Adv Hematol 2010:358283 |
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