Abstract

Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. We have developed methods for studying play behavior, bone density, and language acquisition in 1 and 2 year olds, and completed a pilot recruitment evaluation. For all these studies, the exposed group are children using soy formula, compared with breast fed or cow milk formula.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES044006-12
Application #
8553695
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2012
Total Cost
$534,073
Indirect Cost

  Institution

Name
National Institute of Environmental Health Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Wang, Yan; Rogan, Walter J; Chen, Hsin-Yi et al. (2015) Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study. Int J Hyg Environ Health 218:639-44
Adgent, Margaret A; Rogan, Walter J (2015) Triclosan and prescription antibiotic exposures and enterolactone production in adults. Environ Res 142:66-71
Wang, Yan; Cupul-Uicab, Lea A; Rogan, Walter J et al. (2015) Recreational Exercise Before and During Pregnancy in Relation to Plasma C-Reactive Protein Concentrations in Pregnant Women. J Phys Act Health 12:770-5
Council on Environmental Health; Rogan, Walter J; Paulson, Jerome A et al. (2014) Iodine deficiency, pollutant chemicals, and the thyroid: new information on an old problem. Pediatrics 133:1163-6
Wang, Yan; Chen, Aimin; Dietrich, Kim N et al. (2014) Postnatal exposure to methyl mercury and neuropsychological development in 7-year-old urban inner-city children exposed to lead in the United States. Child Neuropsychol 20:527-38
Wang, Yan; Rogan, Walter J; Chen, Pau-Chung et al. (2014) Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study. Environ Health Perspect 122:529-34
Liu, Jianghong; Liu, Xianchen; Wang, Wei et al. (2014) Blood lead concentrations and children's behavioral and emotional problems: a cohort study. JAMA Pediatr 168:737-45
Adgent, Margaret A; Flake, Gordon P; Umbach, David M et al. (2013) Urogenital epithelial cells as simple markers of estrogen response in infants: methods and applications. PLoS One 8:e77061
Adgent, Margaret A; Daniels, Julie L; Rogan, Walter J et al. (2012) Early-life soy exposure and age at menarche. Paediatr Perinat Epidemiol 26:163-75
Valentín-Blasini, Liza; Blount, Benjamin C; Otero-Santos, Samaret et al. (2011) Perchlorate exposure and dose estimates in infants. Environ Sci Technol 45:4127-32

Showing the most recent 10 out of 18 publications