Abstract

We contributed to several rodent studies that investigated sources of variability in response to genetics and environmental agents. The NTP was considering including environmental enrichment materials (e.g., nesting materials, polycarbonate shelters) in rodent cages within its testing program. We designed a study and analyzed data to confirm that these materials will not affect toxicity endpoints in short-term rat and mouse studies. Some of the NTP Laboratory are investigating effects of environmental exposures on mammary gland development and mammary tumor development. Females of three strains of rats were examined at several time points during puberty to evaluate mammary gland development, including body weight, vaginal opening, hormone receptor binding within the gland, and quantitated mammary gland structure. There was considerable difference in the rate of development among the strains, suggesting that the strains had different windows during which exposure to carcinogens would be informative.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES045003-21
Application #
9550029
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Stanko, Jason P; Kissling, Grace E; Chappell, Vesna A et al. (2016) Differences in the Rate of in Situ Mammary Gland Development and Other Developmental Endpoints in Three Strains of Female Rat Commonly Used in Mammary Carcinogenesis Studies: Implications for Timing of Carcinogen Exposure. Toxicol Pathol 44:1021-33
Churchill, Sheba R; Morgan, Daniel L; Kissling, Grace E et al. (2016) Impact of Environmental Enrichment Devices on NTP In Vivo Studies. Toxicol Pathol 44:233-45
French, John E; Gatti, Daniel M; Morgan, Daniel L et al. (2015) Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity. Environ Health Perspect 123:237-45
Filgo, Adam J; Quist, Erin M; Hoenerhoff, Mark J et al. (2015) Perfluorooctanoic Acid (PFOA)-induced Liver Lesions in Two Strains of Mice Following Developmental Exposures: PPAR? Is Not Required. Toxicol Pathol 43:558-68
Quist, Erin M; Filgo, Adam J; Cummings, Connie A et al. (2015) Hepatic Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures to Low Doses of Perfluorooctanoic Acid (PFOA). Toxicol Pathol 43:546-57
Ramot, Yuval; Kodavanti, Urmila P; Kissling, Grace E et al. (2015) Clinical and pathological manifestations of cardiovascular disease in rat models: the influence of acute ozone exposure. Inhal Toxicol 27 Suppl 1:26-38
Jayes, Friederike L; Burns, Katherine A; Rodriguez, Karina F et al. (2014) The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary. Biol Reprod 90:24
Ray, Mitas; Shockley, Keith; Kissling, Grace (2014) Minimizing Systematic Errors in Quantitative High Throughput Screening Data Using Standardization, Background Subtraction, and Non-Parametric Regression. J Exp Second Sci 3:
Ferguson, Sherry A; Law, Charles Delbert; Kissling, Grace E (2014) Developmental treatment with ethinyl estradiol, but not bisphenol A, causes alterations in sexually dimorphic behaviors in male and female Sprague Dawley rats. Toxicol Sci 140:374-92
Kim, J M; Kosak, J P; Kim, J K et al. (2013) NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory response. Mediators Inflamm 2013:641851

Showing the most recent 10 out of 21 publications