The biostatisticians participating in the statistical consulting service co-authored several research publications in collaboration with scientists within DIR and outisde the DIR. Manuscripts that were published during this year are listed below and there are several more that are either in preparation or in various stages of the review process. Some examples of our collaborative research are as follows: In collaboration with Hewitt et al. (2010), we created a knockout mouse that has no estrogen receptor alpha activity. By examining gene expression in response to exposure to estrogen, we were able to better understand the role of growth factors independent from estrogen receptor alpha. By knocking out the nuclear receptor, TAK1/TR4, in mice, in Kim et al. (2010) we observed structural and functional changes in the brain. In Jefferson et al. (2009), we found that exposure of mice to genistin, a form of genistein found in infant soy formula, during the first five days of life disrupted development and functioning of the female reproductive system later in life. In Schindler et al. (2009) we showed that the protein kinase p38delta plays an important role in skin tumor development.

Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2010
Total Cost
$1,044,432
Indirect Cost
City
State
Country
Zip Code
Kadekar, Sandeep; Peddada, Shyamal; Silins, Ilona et al. (2012) Gender differences in chemical carcinogenesis in National Toxicology Program 2-year bioassays. Toxicol Pathol 40:1160-8
Xu, Mengyuan; Weinberg, Clarice R; Umbach, David M et al. (2011) coMOTIF: a mixture framework for identifying transcription factor and a coregulator motif in ChIP-seq data. Bioinformatics 27:2625-32
Jugessur, Astanand; Shi, Min; Gjessing, HÃ¥kon Kristian et al. (2011) Fetal genetic risk of isolated cleft lip only versus isolated cleft lip and palate: a subphenotype analysis using two population-based studies of orofacial clefts in Scandinavia. Birth Defects Res A Clin Mol Teratol 91:85-92
Beard, John D; Umbach, David M; Hoppin, Jane A et al. (2011) Suicide and pesticide use among pesticide applicators and their spouses in the agricultural health study. Environ Health Perspect 119:1610-5
Bernstein, David I; Kissling, Grace E; Khurana Hershey, Gurjit et al. (2011) Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor ?. J Allergy Clin Immunol 128:418-20
Gao, Jianjun; Xu, Hong; Weinberg, Clarice et al. (2011) An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease. Neurodegener Dis 8:296-9
Clark, Alan B; Lujan, Scott A; Kissling, Grace E et al. (2011) Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ?. DNA Repair (Amst) 10:476-82
O'Hanlon, Terrance P; Rider, Lisa G; Gan, Lu et al. (2011) Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases. Arthritis Res Ther 13:R69
Colaneri, Alejandro; Staffa, Nickolas; Fargo, David C et al. (2011) Expanded methyl-sensitive cut counting reveals hypomethylation as an epigenetic state that highlights functional sequences of the genome. Proc Natl Acad Sci U S A 108:9715-20
Jukic, A M Z; Weinberg, C R; Baird, D D et al. (2011) The association of maternal factors with delayed implantation and the initial rise of urinary human chorionic gonadotrophin. Hum Reprod 26:920-6

Showing the most recent 10 out of 59 publications