The biostatisticians participating in the statistical consulting service co-authored several research publications in collaboration with scientists within DIR and outisde the DIR. Manuscripts that were published during this year are listed below and there are several more that are either in preparation or in various stages of the review process. Some examples of our collaborative research are as follows: In collaboration with Hewitt et al. (2010), we created a knockout mouse that has no estrogen receptor alpha activity. By examining gene expression in response to exposure to estrogen, we were able to better understand the role of growth factors independent from estrogen receptor alpha. By knocking out the nuclear receptor, TAK1/TR4, in mice, in Kim et al. (2010) we observed structural and functional changes in the brain. In Jefferson et al. (2009), we found that exposure of mice to genistin, a form of genistein found in infant soy formula, during the first five days of life disrupted development and functioning of the female reproductive system later in life. In Schindler et al. (2009) we showed that the protein kinase p38delta plays an important role in skin tumor development.

Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2010
Total Cost
$1,044,432
Indirect Cost
City
State
Country
Zip Code
Kadekar, Sandeep; Peddada, Shyamal; Silins, Ilona et al. (2012) Gender differences in chemical carcinogenesis in National Toxicology Program 2-year bioassays. Toxicol Pathol 40:1160-8
Trempus, Carol S; Wei, Sung-Jen; Humble, Margaret M et al. (2011) A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice. Mol Carcinog 50:981-91
Eggesbø, Merete; Moen, Birgitte; Peddada, Shyamal et al. (2011) Development of gut microbiota in infants not exposed to medical interventions. APMIS 119:17-35
Cao, Yang; Chen, Aimin; Jones, Robert L et al. (2011) Efficacy of succimer chelation of mercury at background exposures in toddlers: a randomized trial. J Pediatr 158:480-485.e1
Hill, Georgette D; Moore, Alicia B; Kissling, Grace E et al. (2011) Effects of hormonally active agents on steroid hormone receptor expression and cell proliferation in the myometrium of ovariectomized macaques. Toxicol Pathol 39:508-15
Waggoner, Jenna K; Kullman, Greg J; Henneberger, Paul K et al. (2011) Mortality in the agricultural health study, 1993-2007. Am J Epidemiol 173:71-83
Tubbs, Jacquelyn T; Kissling, Grace E; Travlos, Greg S et al. (2011) Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice. J Am Assoc Lab Anim Sci 50:185-91
Zegre Cannon, Coralie; Kissling, Grace E; Goulding, David R et al. (2011) Analgesic effects of tramadol, carprofen or multimodal analgesia in rats undergoing ventral laparotomy. Lab Anim (NY) 40:85-93
Resnik, David B; Barner, Dionne D; Dinse, Gregg E (2011) Dual-use review policies of biomedical research journals. Biosecur Bioterror 9:49-54
Perdivara, Irina; Peddada, Shyamal D; Miller, Frederick W et al. (2011) Mass spectrometric determination of IgG subclass-specific glycosylation profiles in siblings discordant for myositis syndromes. J Proteome Res 10:2969-78

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