Collaborative research in environmental health sciences

Peddada, Shyamal

Abstract

Several collaborations have been carried out in this project with intramural as well as extramural researchers during the FY 2012-2013 on a wide range of topics. These collaborations have led to several manuscripts that are currently at various stages of publication. Some examples of collaborations are as follows. 1. Study of infant gut microbiome: In addition to the external (chemical) environment, the internal (microbial) environment plays an important role in human health. In recent years there has been considerable interest among researchers to understand the effect of microbiome on various health conditions and diseases, such as obesity, asthma, IBD, depression etc. In collaboration with researchers at the Norwegian Institute of Public Health, in this project we are trying to understand the associations between infant gut microbiome and some early childhood health outcomes. Novel statistical methods are being developed for drawing such associations. 2. Study of DNA methylation in newborns of mothers who smoked during their pregnancy: Maternal smoking during pregnancy is known to be associated with a variety health outcomes in babies. In collaboration with Dr. Stephanie London (EB), we are investigating the effect of maternal smoking during pregnancy on DNA methylation in cord blood obtained from newborns.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAES103066-03
• Application #: 8929817
• Support Year: 3
• Fiscal Year: 2014

Institution

• Name: U.S. National Inst of Environ Hlth Scis

Publications

Hill-Burns, Erin M; Debelius, Justine W; Morton, James T et al. (2017) Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome. Mov Disord 32:739-749

Reese, Sarah E; Zhao, Shanshan; Wu, Michael C et al. (2017) DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy. Environ Health Perspect 125:760-766

Lowe, Julie M; Nguyen, Thuy-Ai; Grimm, Sara A et al. (2017) The novel p53 target TNFAIP8 variant 2 is increased in cancer and offsets p53-dependent tumor suppression. Cell Death Differ 24:181-191

Joubert, Bonnie R; den Dekker, Herman T; Felix, Janine F et al. (2016) Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns. Nat Commun 7:10577

Reber, Stefan O; Siebler, Philip H; Donner, Nina C et al. (2016) Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice. Proc Natl Acad Sci U S A 113:E3130-9

Hayes, Schantel A; Pandiri, Arun R; Ton, Thai-vu T et al. (2016) Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation. Toxicol Pathol 44:71-87

Yamashita, Haruhiro; Hoenerhoff, Mark J; Peddada, Shyamal D et al. (2016) Chemical Exacerbation of Light-induced Retinal Degeneration in F344/N Rats in National Toxicology Program Rodent Bioassays. Toxicol Pathol 44:892-903

Harvey, J B; Hong, H-H L; Bhusari, S et al. (2015) F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgf? Dysregulation. Vet Pathol :

Harvey, Janice B; Osborne, Tanasa S; Hong, Hue-Hua L et al. (2015) Uterine Carcinomas in Tetrabromobisphenol A-exposed Wistar Han Rats Harbor Increased Tp53 Mutations and Mimic High-grade Type I Endometrial Carcinomas in Women. Toxicol Pathol 43:1103-13

Kadiiska, Maria B; Peddada, Shyamal; Herbert, Ronald A et al. (2015) Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress. Free Radic Biol Med 81:100-6