We provide biostatistics expertise for a number of NIEHS and NTP researchers, as well as researchers at universities and other government agencies who are conducting research related to the mission of the NIEHS. In these collaborations, we provide advice about study design, analyze data, interpret statistical results, and participate in writing papers for publication. We collaborated with NIEHS and extramural researchers who are mining survey data to discover associations between environmental exposures and disease. In one study, we examined associations in women between markers of autoimmunity (antinuclear antibodies (ANA)) and hormonal status and reproductive history. We observed that ANA was increased in women who had had at least one child, but was not further increased with the number of children. Use of hormones through contraceptives or estrogen therapy was not associated with ANA prevalence. In other retrospective data-mining studies of surgical treatment of coronary artery disease, we found that thrombosis is more likely several years after a stent is placed in a coronary artery compared to simply expanding the diameter of the artery through angioplasty. In a separate investigation, we found that stents that slowly release drugs as associated with fewer adverse effects than bare metal stents. Finally, in a survey of U.S. research institutions, we characterized policies for providing compensation to research participants who are injured as a result of the research procedures.

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4
Fiscal Year
2015
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U.S. National Inst of Environ Hlth Scis
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Resnik, David B; Konecny, Brandon; Kissling, Grace E (2017) Conflict of Interest and Funding Disclosure Policies of Environmental, Occupational, and Public Health Journals. J Occup Environ Med 59:28-33
Ungewitter, Erica; Rotgers, Emmi; Bantukul, Tanika et al. (2017) From the Cover: Teratogenic Effects of in Utero Exposure to Di-(2-Ethylhexyl)-Phthalate (DEHP) in B6:129S4 Mice. Toxicol Sci 157:8-19
Ogburn, Ryenne N; Randall, Thomas A; Xu, Yingrong et al. (2017) Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins? J Allergy Clin Immunol 139:1030-1032.e1
Castro, Lysandra; Gao, Xioahua; Moore, Alicia B et al. (2016) A High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by Autophagy. Expert Opin Environ Biol 5:
Resnik, David B; Tyler, Ana M; Black, Jennifer R et al. (2016) Authorship policies of scientific journals. J Med Ethics 42:199-202
Blankenship-Paris, Terry L; Dutton, John W; Goulding, David R et al. (2016) Evaluation of buprenorphine hydrochloride Pluronic(®) gel formulation in male C57BL/6NCrl mice. Lab Anim (NY) 45:370-9
Yu, Linda; Ham, Kyle; Gao, Xiaohua et al. (2016) Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling. Cell Commun Signal 14:18
Rodriguez, Karina F; Ungewitter, Erica K; Crespo-Mejias, Yasmin et al. (2016) Response to ""Comment on 'Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice'"". Environ Health Perspect 124:A46-7
Wyss, Annah B; Jones, Anna Ciesielski; Bølling, Anette K et al. (2016) Particulate Matter 2.5 Exposure and Self-Reported Use of Wood Stoves and Other Indoor Combustion Sources in Urban Nonsmoking Homes in Norway. PLoS One 11:e0166440
Resnik, David B; Ariansen, J L; Jamal, Jaweria et al. (2016) Institutional Conflict of Interest Policies at U.S. Academic Research Institutions. Acad Med 91:242-6

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