Cell-cell signaling is a major strategy that vertebrate embryos employ to control their development. We are interested in the mechanistic understanding of a major signaling pathway mediated by Wnts in the control of vertebrate embryonic development, in particular, limb development and skeletal morphogeneis. Early in limb development, signaling molecules which include the Wnt family members determine where and when the late structures, i.e., skeletal elements will form. Skeletal morphogeneis in the limb occurs through endochondral bone formation in which chondrocytes (they form the cartilage) and osteoblasts (they secrete bone matrix) are differentiated from mesenchymal condensations. This is followed by sequential proliferation and maturation of both chondrocytes and osteoblasts, which are tightly regulated and coordinated to ensure proper morphogenesis of the skeletal system. In the past year, we have found that (1) Signaling through G proteins play important roles to modulate Wnt signaling activities both in normal development and in diseases;(2) Hippo signaling is required for liver organ size control and tumor suppression. Wnt signaling may act downstream of the Hippo signaling in liver tumorigenesis. (3) The Wnt/PCP pathway controls left-right asymmetry in early development.
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| Zhao, Haixia; Zhou, Wenrong; Yao, Zhengju et al. (2015) Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol 398:242-54 |
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| Malhotra, Deepti; Yang, Yingzi (2014) Wnts' fashion statement: from body stature to dysplasia. Bonekey Rep 3:541 |
| Qu, Yibo; Huang, Yuhua; Feng, Jia et al. (2014) Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A 111:E2996-3004 |
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| Regard, Jean B; Malhotra, Deepti; Gvozdenovic-Jeremic, Jelena et al. (2013) Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19:1505-12 |
| Andre, Philipp; Yang, Yingzi (2013) Reply to Mazzeu: Human mutations in RYK might cause Robinow syndrome. J Biol Chem 288:2906 |
| Gao, Bo; Yang, Yingzi (2013) Planar cell polarity in vertebrate limb morphogenesis. Curr Opin Genet Dev 23:438-44 |
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