Abstract

Hedgehog (Hh) signaling is required for the differentiation of mesenchymal progenitors into osteoblasts during endochondral bone formation. However, the role of Hh signaling in differentiated osteoblasts during adult bone homeostasis remains to be elucidated. In addition, Hh signaling is also required to control chondrocyte proliferation and hypertrophy. In the past year we found that in the postnatal bone, Hh signaling activity has to be tightly regulated. Abnormal activation of Hh signaling in the bone leads to tumor-like lesions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHG200342-04
Application #
8149450
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2010
Total Cost
$376,516
Indirect Cost

  Institution

Name
National Human Genome Research Institute
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Zhao, Haixia; Zhou, Wenrong; Yao, Zhengju et al. (2015) Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol 398:242-54
Pryor, Sophie E; Massa, Valentina; Savery, Dawn et al. (2014) Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals. Development 141:3153-8
Regard, Jean B; Malhotra, Deepti; Gvozdenovic-Jeremic, Jelena et al. (2013) Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19:1505-12
Hopyan, Sevan; Sharpe, James; Yang, Yingzi (2011) Budding behaviors: Growth of the limb as a model of morphogenesis. Dev Dyn 240:1054-62
Song, Hai; Mak, Kinglun Kingston; Topol, Lilia et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A 107:1431-6
Song, Hai; Hu, Jianxin; Chen, Wen et al. (2010) Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature 466:378-82
Tzchori, Itai; Day, Timothy F; Carolan, Peter J et al. (2009) LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development 136:1375-85
Al-Qattan, Mohammad M; Yang, Yingzi; Kozin, Scott H (2009) Embryology of the upper limb. J Hand Surg Am 34:1340-50
Yang, Yingzi (2009) Growth and patterning in the limb: signaling gradients make the decision. Sci Signal 2:pe3
Yang, Yingzi; Kozin, Scott H (2009) Cell signaling regulation of vertebrate limb growth and patterning. J Bone Joint Surg Am 91 Suppl 4:76-80

Showing the most recent 10 out of 13 publications